Sort the following events to reflect the order in which they occur during vesicle docking onto a target membrane, starting with an inactive Rab in the cytosol. Your answer would be a four-letter string composed of letters A to D only, e.g. DACB.
(A) Rab is bound to its effector (tethering protein) on the target membrane.
(B) Rab is bound to its Rab-GDI.
(C) Rab is bound to the membrane in its GTP-bound form.
(D) Rab dissociates from the membrane.

Question

Sort the following events to reflect the order in which they occur during vesicle docking onto a target membrane, starting with an inactive Rab in the cytosol. Your answer would be a four-letter string composed of letters A to D only, e.g. DACB.
(A)	Rab is bound to its effector (tethering protein) on the target membrane.
(B)	Rab is bound to its Rab-GDI.
(C)	Rab is bound to the membrane in its GTP-bound form.
(D)	Rab dissociates from the membrane.

Quizplus · Accepted Answer

In its GDP-bound form, a Rab protein is bound to a Rab-GDP dissociation inhibitor and kept in the cytosol. Once activated by a membrane-bound Rab-GEF and bound to GTP, Rab molecules associate with the membrane through a lipid anchor and bind to their effector proteins. Finally, GTP hydrolysis results in Rab inactivation and dissociation from the membrane.

Sort the Following Events to Reflect the Order in Which