Phosphoinositides mark different cellular membranes and play key roles in protein trafficking inside the cell. Among them, PI(4,5)P₂ is involved in receptor-mediated endocytosis as well as phagocytosis at the plasma membrane. This phosphoinositide …

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AP2 adopts an open conformation once bound to PI(4,5)P₂ in the plasma membrane. Dynamin also has a PI(4,5)P₂?-binding domain which tethers the protein to the membrane as a clathrin-coated bud grows. Once clathrin-coated vesicles pinch off from the membrane, a PIP phosphatase that is co-packaged into the vesicles depletes PI(4,5)P₂, which weakens the binding of the adaptor proteins.

Phosphoinositides Mark Different Cellular Membranes and Play Key Roles in Protein