Indicate true (T) and false (F) statements below regarding glycosylation of proteins in the endoplasmic reticulum and the Golgi apparatus. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF
( ) Glycosylation can promote protein folding.
( ) The glycosylation state of a protein can determine its fate along the secretory pathway.
( ) Glycosylation makes a protein more accessible to proteases and other proteins.
( ) Glycosylated proteins are generally more flexible.

Question

Indicate true (T) and false (F) statements below regarding glycosylation of proteins in the endoplasmic reticulum and the Golgi apparatus. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF
( )	Glycosylation can promote protein folding.
( )	The glycosylation state of a protein can determine its fate along the secretory pathway.
( )	Glycosylation makes a protein more accessible to proteases and other proteins.
( )	Glycosylated proteins are generally more flexible.

Quizplus · Accepted Answer

Chains of sugar have limited flexibility and therefore protrude from the protein surface. As a result, the approach of other macromolecules to the protein is limited. At the same time, lectins can recognize the sugar chain and control the proper folding of the protein or send it down a particular sorting pathway.

Indicate True (T) and False (F) Statements Below Regarding Glycosylation