How does the affinity of M6P receptor proteins for the mannose 6-phosphate marker change between the TGN and early endosome? Which coat protein is mainly responsible for their transport from the TGN to the endosome?

Question

Quizplus · Accepted Answer

In the trans Golgi network (TGN), mannose 6-phosphate (M6P) receptor proteins bind to hydrolases that carry the M6P group and mediate their incorporation into clathrin-coated vesicles destined for endosomes. In the lower pH of the endosome lumen, the hydrolases are released and the receptor proteins are retrieved by incorporation in retromer-coated vesicles.

How Does the Affinity of M6P Receptor Proteins for the Mannose