In the following simplified diagram, the activation of a hypothetical allosteric protein is plotted as a function of effector molecule concentration. Which curve (A to E) do you think corresponds to a condition in which activation requires the highest number of effector molecules bound to each protein?

Question

In the following simplified diagram, the activation of a hypothetical allosteric protein is plotted as a function of effector molecule concentration. Which curve (A to E) do you think corresponds to a condition in which activation requires the highest number of effector molecules bound to each protein? In the following simplified diagram, the activation of a hypothetical allosteric protein is plotted as a function of effector molecule concentration. Which curve (A to E) do you think corresponds to a condition in which activation requires the highest number of effector molecules bound to each protein?

Quizplus · Accepted Answer

The sharpness of the sigmoidal activation response increases with an increase in the number of effector molecules that must be bound simultaneously for complete activation of the target protein.

In the Following Simplified Diagram, the Activation of a Hypothetical