Indicate true (T) and false (F) statements below regarding the ubiquitin ligase c-Cbl. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) It contains an SH2 domain, and can therefore activate RTK signaling.
( ) It ubiquitylates activated RTKs.
( ) Its overactivation can lead to prolonged RTK signaling and promote the development of cancer.
( ) It is part of a negative feedback loop to down-regulate RTKs.

Question

Indicate true (T) and false (F) statements below regarding the ubiquitin ligase c-Cbl. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( )	It contains an SH2 domain, and can therefore activate RTK signaling.
( )	It ubiquitylates activated RTKs.
( )	Its overactivation can lead to prolonged RTK signaling and promote the development of cancer.
( )	It is part of a negative feedback loop to down-regulate RTKs.

Quizplus · Accepted Answer

T
F
T
 c-Cbl is a ubiquitin ligase that is recruited to activated receptor tyrosine kinases (RTKs) through its SH2 domain and inactivates the receptors in a negative feedback loop. Mutations that inactivate this feedback mechanism cause prolonged RTK signaling and can promote the development of cancer.

Indicate True (T) and False (F) Statements Below Regarding the Ubiquitin