Indicate true (T) and false (F) statements below regarding the Ras-MAP-kinase signaling pathway. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) The immediate early genes turn on a few hours after activation of the RTK.
( ) Ras-GTP binds directly to, and activates, the upstream kinase in the MAP kinase module.
( ) Signal transduction through the Ras-MAP-kinase pathway only leads to a transient response.
( ) In the MAP kinase module, Raf can be phosphorylated by Erk to create a negative feedback loop.

Question

Indicate true (T) and false (F) statements below regarding the Ras-MAP-kinase signaling pathway. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( )	The immediate early genes turn on a few hours after activation of the RTK.
( )	Ras-GTP binds directly to, and activates, the upstream kinase in the MAP kinase module.
( )	Signal transduction through the Ras-MAP-kinase pathway only leads to a transient response.
( )	In the MAP kinase module, Raf can be phosphorylated by Erk to create a negative feedback loop.

Quizplus · Accepted Answer

The mitogen-activated protein kinase (MAP kinase) module in the mammalian Ras-MAP-kinase signaling pathway is composed of Raf, Mek, and Erk. Stimulation of receptor tyrosine kinases (RTKs) at the cell surface can activate Ras, which then triggers the MAP kinase cascade. Once activated, Erk relays the signal downstream, leading to transient or long-lasting responses. Erk can also regulate Raf activity through negative feedback loops. The immediate early genes are typically activated minutes after RTK stimulation.

Indicate True (T) and False (F) Statements Below Regarding the Ras-MAP-Kinase