Indicate true (T) and false (F) statements below regarding the mTOR complexes. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) mTOR in complex 1 contains the protein raptor, is sensitive to rapamycin, and stimulates cell growth.
( ) Akt activation is stimulated by mTOR in complex 2, which contains the protein rictor.
( ) Akt activates mTOR in complex 2 by activating a Rheb-GAP called Tsc2.
( ) mTOR in complex 1 is activated in the presence of growth factors.

Question

Indicate true (T) and false (F) statements below regarding the mTOR complexes. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( )	mTOR in complex 1 contains the protein raptor, is sensitive to rapamycin, and stimulates cell growth.
( )	Akt activation is stimulated by mTOR in complex 2, which contains the protein rictor.
( )	Akt activates mTOR in complex 2 by activating a Rheb-GAP called Tsc2.
( )	mTOR in complex 1 is activated in the presence of growth factors.

Quizplus · Accepted Answer

mTOR complex 1 is rapamycin-sensitive, and is activated in the presence of growth factors, mainly via the PI-3-kinase-Akt pathway, to stimulate cell growth. Akt phosphorylates and inhibits Tsc2, a Rheb-GAP. This activates Rheb, which then activates mTOR in complex 1.

Indicate True (T) and False (F) Statements Below Regarding the MTOR