The SH2 domain of STAT proteins plays a key role in cytokine receptor signaling. This domain can bind to phosphotyrosine ...
A) on an activated receptor molecule, or (intramolecularly) on the same STAT molecule.
B) on a Janus kinase molecule, or (intramolecularly) on the same STAT molecule.
C) on an activated receptor molecule, or on another STAT molecule in a dimer.
D) on a Janus kinase molecule, or on another STAT molecule in a dimer.
E) on the same STAT molecule or on another STAT molecule in a dimer.

Question

Quizplus · Accepted Answer

Each STAT has an SH2 domain with two functions: it mediates STAT binding to an activated cytokine receptor; after JAK phosphorylation of STAT, it mediates binding between two STAT molecules in a dimer.

The SH2 Domain of STAT Proteins Plays a Key Role