A small unique insert found near the end of the motor domain in myosin VI has been linked to the singular ability of this myosin to move toward the pointed end of actin filaments. If the unique insert is removed by genetic engineering, the resulting mutant myosin VI is a plus-end directed motor. This observation indicates that …
A) the unique insert is necessary and sufficient for minus-end directionality.
B) the unique insert is necessary for motor activity.
C) the unique insert is necessary for plus-end directed directionality.
D) the unique insert is not sufficient for minus-end directionality.
E) None of the above.

Question

Quizplus · Accepted Answer

The result shows that the unique insert is necessary for the minus-end directionality of myosin VI, but not necessary for its motor activity. The experiment does not address the sufficiency of the insert.

A Small Unique Insert Found near the End of the Motor