Dynamitin is a subunit of the dynactin complex. Its overexpression leads to the disassembly of the complex, and it is therefore considered a dynactin inhibitor. Which of the following processes would happen if dynamitin is overexpressed in a cell?
A) The motile cilia (if any) would stop beating because the axonemal dyneins could not attach to their neighboring microtubules.
B) The Golgi apparatus would fragment and become dispersed because the cytoplasmic dyneins could not associate with the Golgi membranes.
C) The endoplasmic reticulum would collapse because it could not recruit enough kinesins.
D) The nuclear envelope would disintegrate because the nuclear lamins could not interact with the cytoplasmic cytoskeleton.
E) The cortex would lose its integrity because the Arp 2/3 complex would also be inhibited.

Question

Quizplus · Accepted Answer

Cytoplasmic dyneins rely on the dynactin complex to associate with their cargoes, including the Golgi components, which are held near the center of the cell by the action of these motors.

Dynamitin Is a Subunit of the Dynactin Complex