The pathogen Listeria monocytogenes can hijack the actin cytoskeleton in human cells and spread inside the host. Indicate true (T) and false (F) statements below about this phenomenon. Your answer would be a four-letter string composed of letters T and F only; e.g. TTFF.
( ) The movement can be reconstituted in vitro by placing the bacteria in a mixture of actin, formin, gelsolin, and capping protein.
( ) Cofilin counteracts the movement by depolymerizing actin filaments.
( ) The actin filaments grow with their minus ends pointed toward the bacterium.
( ) The movement depends on myosin activity to transport the bacteria on the actin filaments.

Question

The pathogen Listeria monocytogenes can hijack the actin cytoskeleton in human cells and spread inside the host. Indicate true (T) and false (F) statements below about this phenomenon. Your answer would be a four-letter string composed of letters T and F only; e.g. TTFF.
( )	The movement can be reconstituted in vitro by placing the bacteria in a mixture of actin, formin, gelsolin, and capping protein.
( )	Cofilin counteracts the movement by depolymerizing actin filaments.
( )	The actin filaments grow with their minus ends pointed toward the bacterium.
( )	The movement depends on myosin activity to transport the bacteria on the actin filaments.

Quizplus · Accepted Answer

The bacterium recruits and activates the Arp 2/3 complex at its surface. The force generated by actin polymerization at the plus end pushes the bacterium, while cofilin and capping protein ensure continuous motion and prevent the depletion of free actin subunits by promoting filament turnover.

The Pathogen Listeria Monocytogenes Can Hijack the Actin Cytoskeleton in Human