Considering the diagram below, which summarizes two signaling pathways initiated by activated GTPases of the Rho family, what letter (A to D) corresponds to each of the following? Your answer would be a four-letter string composed of letters A to D only, e.g. ABCD.

( ) Rac-GTP
( ) Rho-GTP
( ) Lamellipodia formation
( ) Stress-fiber formation

Question

Considering the diagram below, which summarizes two signaling pathways initiated by activated GTPases of the Rho family, what letter (A to D) corresponds to each of the following? Your answer would be a four-letter string composed of letters A to D only, e.g. ABCD.
  
( )	Rac-GTP
( )	Rho-GTP
( )	Lamellipodia formation
( )	Stress-fiber formation

Quizplus · Accepted Answer

Rac-GTP (B) promotes lamellipodium formation (D) by activating WASp family members, which leads to the nucleation of branched actin networks by the Arp 2/3 complex, as well as by activating filamin, a gel-forming actin cross-linker. Rho-GTP (A), on the other hand, activates formin to create parallel actin bundles, inhibits cofilin to stabilize actin filaments, and increases myosin motor activity, which all lead to formation of more stress fibers (C).

Considering the Diagram Below, Which Summarizes Two Signaling Pathways Initiated