In a multicellular organism such as a mammal, loss-of-function mutations in many genes can contribute to the development of cancer. These genes are therefore called tumor suppressors. In their absence, the cell fails to stop progression through the cell cycle under conditions in which normal cells would arrest, paving the way for tumorigenesis. Indicate whether each of the following proteins is (Y) or is not (N) expected to be the product of a tumor suppressor gene based on its function in the cell cycle. Your answer would be a four-letter string composed of letters Y and N only, e.g. YNNN.
( ) Rb
( ) Myc
( ) p53
( ) p21

Question

In a multicellular organism such as a mammal, loss-of-function mutations in many genes can contribute to the development of cancer. These genes are therefore called tumor suppressors. In their absence, the cell fails to stop progression through the cell cycle under conditions in which normal cells would arrest, paving the way for tumorigenesis. Indicate whether each of the following proteins is (Y) or is not (N) expected to be the product of a tumor suppressor gene based on its function in the cell cycle. Your answer would be a four-letter string composed of letters Y and N only, e.g. YNNN.
( )	Rb
( )	Myc
( )	p53
( )	p21

Quizplus · Accepted Answer

Loss-of-function mutations in p53, Rb, and p21 are found in human cancers. Myc, on the other hand, has the opposite effect: gain-of-function mutations in Myc can drive cancer.

In a Multicellular Organism Such as a Mammal, Loss-Of-Function Mutations