Indicate true (T) and false (F) statements below regarding fibronectin in the extracellular matrix. Your answer would be a four-letter string composed of letters T and F only, e.g. TFTT.
( ) Fibronectin carries asparagine-linked oligosaccharides.
( ) Fibronectin often forms homodimers by cross-linking through covalent attachment of lysine residues.
( ) Fibronectin binds to integrins, collagens, and glycosaminoglycans through its type III repeats.
( ) Fibronectin molecules can assemble into fibrils only in the vicinity of cells.

Question

Indicate true (T) and false (F) statements below regarding fibronectin in the extracellular matrix. Your answer would be a four-letter string composed of letters T and F only, e.g. TFTT.
( )	Fibronectin carries asparagine-linked oligosaccharides.
( )	Fibronectin often forms homodimers by cross-linking through covalent attachment of lysine residues.
( )	Fibronectin binds to integrins, collagens, and glycosaminoglycans through its type III repeats.
( )	Fibronectin molecules can assemble into fibrils only in the vicinity of cells.

Quizplus · Accepted Answer

Fibronectin is a matrix multidomain glycoprotein and can form fibronectin fibrils on the surface of cells. This assembly is regulated by the tension exerted by the cells via surface proteins such as integrins. Type III fibronectin repeats are responsible for integrin binding, whereas binding to collagen and heparin is mediated by type I and type II repeats. Fibronectin heterodimers are held together by C-terminal disulfide bonds.

Indicate True (T) and False (F) Statements Below Regarding Fibronectin