Indicate whether each of the following descriptions better applies to the intracellular (I) or extracellular (E) domain of integrins. Your answer would be a four-letter string composed of letters I and E only, e.g. EEEE.
( ) It binds to talin.
( ) It binds to the RGD tripeptide motif.
( ) It is bulkier.
( ) It contains divalent cation-binding domains.

Question

Indicate whether each of the following descriptions better applies to the intracellular (I) or extracellular (E) domain of integrins. Your answer would be a four-letter string composed of letters I and E only, e.g. EEEE.
( )	It binds to talin.
( )	It binds to the RGD tripeptide motif.
( )	It is bulkier.
( )	It contains divalent cation-binding domains.

Quizplus · Accepted Answer

The large N-terminal extracellular domain of integrins can bind to proteins containing the RGD or other sequences. The binding is modulated by the concentration of divalent ions such as Ca²?. The intracellular domain can engage the actin cytoskeleton or the intermediate filaments by using adaptor proteins such as talin and plectin, respectively.

Indicate Whether Each of the Following Descriptions Better Applies to the Intracellular