A cell's response is not the same when placed on a rigid compared to a soft matrix. Indicate whether each of the following is expected to occur in a cell that is placed on a rigid matrix (R) or a soft matrix (S). Your answer would be a three-letter string composed of letters R and S only, e.g. RSR.
( ) More tension is generated in cell-matrix contacts.
( ) More vinculin proteins would bind to the C-terminal tail of talin.
( ) More actin filaments are recruited to the site of cell-matrix adhesion.

Question

A cell's response is not the same when placed on a rigid compared to a soft matrix. Indicate whether each of the following is expected to occur in a cell that is placed on a rigid matrix (R) or a soft matrix (S). Your answer would be a three-letter string composed of letters R and S only, e.g. RSR.
( )	More tension is generated in cell-matrix contacts.
( )	More vinculin proteins would bind to the C-terminal tail of talin.
( )	More actin filaments are recruited to the site of cell-matrix adhesion.

Quizplus · Accepted Answer

When the cell is placed on a rigid substratum that strongly resists pulling forces applied at the cell-matrix junctions, the increased tension is sensed by the junction and more proteins are recruited to the junction as a result.

A Cell's Response Is Not the Same When Placed on a Rigid