Indicate whether each of the following normally occurs before (B) or after (A) antigen stimulation of B cells. Your answer would be a four-letter string composed of letters A and B only, e.g. AAAA.
( ) V(D)J recombination
( ) Class switch recombination
( ) Somatic hypermutation
( ) Junctional diversification

Question

Indicate whether each of the following normally occurs before (B) or after (A) antigen stimulation of B cells. Your answer would be a four-letter string composed of letters A and B only, e.g. AAAA.
( )	V(D)J recombination
( )	Class switch recombination
( )	Somatic hypermutation
( )	Junctional diversification

Quizplus · Accepted Answer

Before they can make immunoglobulin (Ig) molecules and thereby bind antigen, B cells have to undergo V(D)J recombination, which is accompanied by junctional diversification. After stimulation with an antigen, B cells undergo somatic hypermutation (as part of their affinity maturation) and class switch recombination (as part of Ig class switching).

Indicate Whether Each of the Following Normally Occurs Before (B)