Phenytoin, a common drug used to treat epilepsy, interacts with which of the following nutrients?

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Phenytoin has been shown to decrease serum folate levels, potentially leading to folate deficiency. This can be especially concerning for pregnant women taking the medication as folate is important for fetal development. Supplementation with folate may be necessary to prevent deficiency. Phenytoin can decrease the absorption of folate, leading to a deficiency. This deficiency can cause anemia, birth defects in pregnant women, and increased risk of cardiovascular disease. It is recommended to supplement with folic acid while taking phenytoin. There is no evidence that phenytoin interacts with vitamin B12, biotin, or thiamin.

Phenytoin, a Common Drug Used to Treat Epilepsy, Interacts with Which