What Was the Significance of Harriet Beecher Stowe's Uncle Tom's

What was the significance of Harriet Beecher Stowe's Uncle Tom's Cabin ?

A) It contradicted prevailing stereotypes about blacks.
B) It challenged the common notion that slavery tore apart the black family.
C) It pushed many waverers to an aggressive antislavery stance.
D) It strengthened the southern defense of slavery by reinforcing stereotypes of blacks as docile and inferior.
E) It sold relatively few copies and was soon out of print.