The Warburg Effect Is the Observation That Cancer Cells Produce

The Warburg effect is the observation that cancer cells produce energy using a high rate of glycolysis followed by fermentation rather than oxidative phosphorylation. Although the exact cause is still under investigation, which explanation is most plausible?

A) Tumors attract blood vessels to increase levels of available oxygen.
B) In order to grow quickly, high levels of ATP are required.
C) Mutations in phosphofructokinase prevent feedback inhibition.
D) Tumor formation upregulates glycolytic proteins.
E) Rapid cell proliferation damages mitochondrial function.