What is the name of the type of chemical modification on anti-miRNA oligonucleotides used to inhibit miRNA function that involves ribose sugars with an extra bridge connecting the 2' oxygen and the 4' carbon?
A) Locked nucleic acids
B) Antagomirs
C) Enoxacin
D) RNaseMRP

Question

Quizplus · Accepted Answer

The description matches that of locked nucleic acids (LNAs), which are modified ribonucleotides with a bridge connecting the 2' oxygen and the 4' carbon, locking the ribose into a rigid conformation. LNAs are used to increase the stability and affinity of antisense oligonucleotides, including anti-miRNA oligonucleotides, leading to improved inhibition of miRNA function. Antagomirs, on the other hand, are chemically modified single-stranded RNA molecules that are complementary to specific miRNAs and can therefore inhibit their activity. Enoxacin is a small molecule antibiotic that has been shown to inhibit miRNA biogenesis by targeting the RNA helicase DDX5/17. RNaseMRP is a ribonucleoprotein complex involved in the processing of precursor ribosomal RNA (rRNA) and other non-coding RNAs.

What Is the Name of the Type of Chemical Modification