Biologists investigating the morphologic changes associated with reversible cellular injury perform a procedure on anesthetized mice to assess the effects of transient hepatic ischemia. During the experiment, they clamp the hepatic artery and obtain liver biopsy samples at varying intervals. The samples are then examined by electron microscopy. Cells that are exposed to longer ischemic periods are found to have reduced numbers of ribosomes attached to the endoplasmic reticulum. This structural change is most likely to impair which of the following cellular functions?

Question

Biologists investigating the morphologic changes associated with reversible cellular injury perform a procedure on anesthetized mice to assess the effects of transient hepatic ischemia.  During the experiment, they clamp the hepatic artery and obtain liver biopsy samples at varying intervals.  The samples are then examined by electron microscopy.  Cells that are exposed to longer ischemic periods are found to have reduced numbers of ribosomes attached to the endoplasmic reticulum.  This structural change is most likely to impair which of the following cellular functions?

Quizplus · Accepted Answer

Eductional Objective: The rough endoplasmic reticulum (RER) is covered with ribosomes and is involved in the transfer of proteins to the cell membrane and extracellular space.  The RER is well developed in protein-secreting cells.  The smooth ER lacks surface ribosomes and functions in lipid synthesis, carbohydrate metabolism, and detoxification of harmful substances.

Biologists Investigating the Morphologic Changes Associated with Reversible Cellular Injury