A biologist is studying signal transduction apply an agent to human cells that activates G-protein- dependent phospholipase C. Which of the following intracellular substances is most likely to increase immediately after exposure to this agent?

Question

A biologist is studying signal transduction apply an agent to human cells that activates G-protein- dependent phospholipase C.  Which of the following intracellular substances is most likely to increase immediately after exposure to this agent?

Quizplus · Accepted Answer

Eductional Objective: The phosphoinositol second messenger system begins with ligand-receptor binding and G_q-protein activation leading to activation of phospholipase C (PLC). PLC then hydrolyzes phosphatidyl inositol bisphosphate and forms diacylglycerol and inositol triphosphate (IP₃). Finally, IP₃ activates protein kinase C via an increase in intracellular Ca²⁺.

A Biologist Is Studying Signal Transduction Apply an Agent to Human