A 15-Year-Old Girl Is Brought to the Office Because She

A 15-year-old girl is brought to the office because she is experiencing amenorrhea. She has never menstruated, although her mother did at the age of 14. The patient does not have any chronic medical issues and does not use any medications. She does not smoke, drink, or use illegal drugs. The patient is the captain of her junior varsity tennis team and plays violin for her high school orchestra. She has no sexual desires. Weight is 65 kg and height is 175.3 cm (5 ft 9 in) (143.3 lb) . 21.2 kg/m² is the BMI. Secondary sexual features are fully established, according to the examination. A shorter vaginal canal with a rudimentary uterus is shown on a pelvic ultrasound. Which of the following diagnoses is more likely?

A) 21-hydroxylase deficiency
B) Androgen insensitivity syndrome
C) Kallmann syndrome
D) Klinefelter syndrome
E) Müllerian agenesis