A 22-year-old man visits the clinic because he has periodic dull headaches that wake him up from sleep. There are no related neurologic impairments in the patient. There is no family history of migraines. His temperature is 37.2 degrees Celsius (99 degrees Fahrenheit), his blood pressure is 140/80 mm Hg, his pulse is 60 beats per minute, and his respirations are 12 beats per minute. On physical examination, his trunk has multiple 3- to 5-cm flat, pigmented patches. On his trunk and neck, there are also many subcentimeter soft, fleshy, cutaneous tumors. Which of the following structures is most likely the source of the majority cells developing these skin tumors?

Question

Quizplus · Accepted Answer

Eductional Objective: Neurofibromatosis type I (von Recklinghausen disease) is an autosomal dominant illness caused by NF1 tumor suppressor gene mutations. Patients often develop many cutaneous neurofibromas composed primarily of Schwann cells, which are formed from the neural crest embryologically.

A 22-Year-Old Man Visits the Clinic Because He Has Periodic