A research is being carried out to evaluate the potential therapeutic benefit and treatment-related toxicity of tandutinib in combination with bevacizumab in patients with recurrent glioblastoma. The research included 41 individuals with recurrent, bevacizumab-naive glioblastoma. Starting on day 15, the treatment consisted of tandutinib 500 mg twice day and bevacizumab 10 mg/kg every 2 weeks. According to the study findings, all patients had treatment-related toxicities; the most prevalent grade 3 toxicities were hypertension (17.1%), muscular weakness (17.1%), lymphopenia (14.6%), and hypophosphatemia (9.8 percent ). The data was then compared to prior clinical trial findings evaluating the therapeutic benefit of bevacizumab monotherapy. They concluded that tandutinib in combination with bevacizumab was as efficacious but more harmful than bevacizumab alone. Which of the following statements best defines this sort of research?

Question

Quizplus · Accepted Answer

Eductional Objective: A phase II clinical trial evaluates therapy effectiveness and side effects in a small number of patients (ie, those with the disease of interest). To assess the potential benefit of the new therapy, the findings are frequently compared to those of earlier clinical trials (ie, historic controls).

A Research Is Being Carried Out to Evaluate the Potential