A 62-year-old man with diabetes, hypertension, and hyperlipidemia arrives at an academic medical center's emergency room complaining of chest discomfort, nausea, vomiting, and diaphoresis. An ECG reveals ST elevation in the anterior leads, as well as substantially increased cardiac enzymes. The center's researchers are planning a randomized controlled study to explore the hypothesis that medication B will reduce the mortality associated with acute ST-elevation myocardial infarction relative to standard of care. Which of the following would investigators want to optimize to guarantee that they do not miss a difference between medication B and standard of treatment (if one exists)?

Question

Quizplus · Accepted Answer

Eductional Objective: Power (1 - B) is the probability of rejecting a null hypothesis when it is truly false.  It is typically set at 80% and depends on sample size and difference between outcomes.

A 62-Year-Old Man with Diabetes, Hypertension, and Hyperlipidemia Arrives at an Academic