In patients with severe aortic stenosis, a randomized controlled trial is being conducted to compare transcatheter aortic valve replacement (TAVR) with surgical aortic valve replacement using a self-expanding transcatheter aortic valve bioprosthesis. The goal is to calculate the difference in risk of mortality from any cause. Seven hundred forty-seven patients with severe aortic stenosis who are at high surgical risk are recruited and randomly randomized to TAVR or surgical valve replacement groups. Following discharge, there are follow-up examinations at one month, six months, and one year. The following are the 1-year follow-up results: Which of the following better depicts the absolute risk decrease for mortality from any cause in TAVR patients compared to surgical replacement patients?

Question

In patients with severe aortic stenosis, a randomized controlled trial is being conducted to compare transcatheter aortic valve replacement (TAVR) with surgical aortic valve replacement using a self-expanding transcatheter aortic valve bioprosthesis. The goal is to calculate the difference in risk of mortality from any cause. Seven hundred forty-seven patients with severe aortic stenosis who are at high surgical risk are recruited and randomly randomized to TAVR or surgical valve replacement groups. Following discharge, there are follow-up examinations at one month, six months, and one year. The following are the 1-year follow-up results:  Which of the following better depicts the absolute risk decrease for mortality from any cause in TAVR patients compared to surgical replacement patients?

Quizplus · Accepted Answer

Eductional Objective: Absolute risk reduction (ARR) describes the difference in risk between control and treatment groups. It is calculated as follows: ARR = (Riskcontrol - Risktreatment).

In Patients with Severe Aortic Stenosis, a Randomized Controlled Trial