A 15-year-old patient is referred to the physician by a teacher who is concerned about the patient's learning abilities and behavior. The patient's reading and writing skills are significantly impaired compared to other classmates, and the patient often misbehaves in class despite receiving numerous detentions. Neuropsychological assessment shows mild intellectual disability. Cytogenetic studies show a karyotype containing 47 chromosomes. Which of the following findings are most likely to be present on further evaluation?

Question

A 15-year-old patient is referred to the physician by a teacher who is concerned about the patient's learning abilities and behavior.  The patient's reading and writing skills are significantly impaired compared to other classmates, and the patient often misbehaves in class despite receiving numerous detentions.  Neuropsychological assessment shows mild intellectual disability.  Cytogenetic studies show a karyotype containing 47 chromosomes.  Which of the following findings are most likely to be present on further evaluation?

Quizplus · Accepted Answer

Eductional Objective: 47,XXY is the most common genotype causing Klinefelter syndrome.  Patients present with tall stature; small, firm testes; azoospermia; and gynecomastia.  Mild intellectual disability is seen in some patients, and the severity generally increases with each additional X chromosome.

A 15-Year-Old Patient Is Referred to the Physician by a Teacher