Preventive disease specialists working in a developing country are investigating vaccination options to limit the spread of poliomyelitis. As part of the study, 2 patients are vaccinated against poliomyelitis. One patient receives an intramuscular inactivated vaccine and the other patient receives a live attenuated oral vaccine. One month after vaccination, the levels of which of the following poliovirus antibodies will differ the most between these 2 patients?

Question

Preventive disease specialists working in a developing country are investigating vaccination options to limit the spread of poliomyelitis.  As part of the study, 2 patients are vaccinated against poliomyelitis.  One patient receives an intramuscular inactivated vaccine and the other patient receives a live attenuated oral vaccine.  One month after vaccination, the levels of which of the following poliovirus antibodies will differ the most between these 2 patients?

Quizplus · Accepted Answer

Eductional Objective: The live attenuated oral (Sabin) poliovirus vaccine produces a stronger mucosal secretory IgA immune response than does the inactivated poliovirus (Salk) vaccine.  This increase in mucosal IgA offers immune protection at the site of viral entry by inhibiting attachment to intestinal epithelial cells.

Preventive Disease Specialists Working in a Developing Country Are Investigating