A 57-year-old woman with autosomal dominant polycystic kidney disease develops end-stage renal disease and undergoes deceased-donor kidney transplantation. During the operation, the surgeon notices that the graft becomes cyanotic and mottled soon after its blood vessels are connected with those of the recipient. Blood flow to the graft ceases, and no urine is produced. Which of the following best explains the findings observed by the surgeon?

Question

A 57-year-old woman with autosomal dominant polycystic kidney disease develops end-stage renal disease and undergoes deceased-donor kidney transplantation.  During the operation, the surgeon notices that the graft becomes cyanotic and mottled soon after its blood vessels are connected with those of the recipient.  Blood flow to the graft ceases, and no urine is produced.  Which of the following best explains the findings observed by the surgeon?

Quizplus · Accepted Answer

Eductional Objective: Hyperacute rejection is caused by preformed antibodies in the recipient that recognize and attack donor antigens (ie, type II hypersensitivity).  These are often anti-ABO blood group or anti-HLA antibodies.  Vascular injury and capillary thrombotic occlusion lead to rapid ischemic necrosis of the renal graft, often evidenced by gross cyanosis and mottling immediately following graft perfusion

A 57-Year-Old Woman with Autosomal Dominant Polycystic Kidney Disease Develops