An autopsy is performed on an 8-month-old infant after his unexpected death. Prior to death, the patient had a 1-month history of poor feeding and intermittent fever, which progressed to severe lethargy and coma. The infant was adopted soon after birth, and there is limited information about his family history beyond documentation of an uncomplicated pregnancy and delivery at term gestation. Brain biopsy reveals leptomeningeal inflammation and is positive for Enterovirus by PCR. This patient would have been most likely to have which of the following laboratory findings?

Question

An autopsy is performed on an 8-month-old infant after his unexpected death.  Prior to death, the patient had a 1-month history of poor feeding and intermittent fever, which progressed to severe lethargy and coma.  The infant was adopted soon after birth, and there is limited information about his family history beyond documentation of an uncomplicated pregnancy and delivery at term gestation.  Brain biopsy reveals leptomeningeal inflammation and is positive for Enterovirus by PCR.  This patient would have been most likely to have which of the following laboratory findings?

Quizplus · Accepted Answer

Eductional Objective: X-linked agammaglobulinemia, an immunodeficiency characterized by low circulating B lymphocytes and immunoglobulins, should be suspected in an infant with severe, life-threatening enteroviral infection.

An Autopsy Is Performed on an 8-Month-Old Infant After His