A 19-year-old man comes to the office with an ulcer on his penis. The patient first noticed the lesion 3 days ago. His temperature is 37.1 C (98.8 F). Physical examination shows an indurated and painless ulcer near the glans penis, with no surrounding erythema and no inguinal lymphadenopathy. The patient is a college student. He has no significant past medical history and takes no medications. He has no known drug allergies. The first-line treatment for this patient has structural similarities with which of the following?

Question

A 19-year-old man comes to the office with an ulcer on his penis.  The patient first noticed the lesion 3 days ago.  His temperature is 37.1 C (98.8 F).  Physical examination shows an indurated and painless ulcer near the glans penis, with no surrounding erythema and no inguinal lymphadenopathy.  The patient is a college student.  He has no significant past medical history and takes no medications.  He has no known drug allergies.  The first-line treatment for this patient has structural similarities with which of the following?

Quizplus · Accepted Answer

Eductional Objective: Penicillins, structurally similar to D-alanine-D-alanine, inhibit transpeptidase by binding covalently to its active site.  The result is failed synthesis of the bacterial peptidoglycan cell wall.

A 19-Year-Old Man Comes to the Office with an Ulcer