A 5-year-old boy is brought by his mother because of a diffculty walking. He has multiple respiratory infections. Cultured cells from this patient demonstrate a high rate of radiation-induced genetic mutation. This patient is most likely to experience which of the following?

Question

A 5-year-old boy is brought by his mother because of a diffculty walking. He has multiple respiratory infections. Cultured cells from this patient demonstrate a high rate of radiation-induced genetic mutation.  This patient is most likely to experience which of the following?

Quizplus · Accepted Answer

Eductional Objective: Ataxia-telangiectasia is an autosomal-recessive disorder resulting from a defect in DNA-repair genes.  The DNA of these patients is hypersensitive to ionizing radiation.  Manifestations include cerebellar ataxia, oculocutaneous telangiectasias, repeated sinopulmonary infections, and an increased incidence of malignancy.

A 5-Year-Old Boy Is Brought by His Mother Because of a Diffculty