A 40-year-old man comes to the physician because of a 2-year history of gradually worsening shortness of breath. He smoked half a pack of cigarettes daily for 10 years but stopped 8 years ago. His pulse is 72/min, blood pressure is 135/75 mm Hg, and respirations are 20/min. Examination shows an increased anteroposterior diameter of the chest. Diminished breath sounds are heard on auscultation of the chest. Spirometry shows an FEV1:FVC ratio of 63% and an FEV1 of 65% of predicted. This patient's lower lung lobes are most likely to demonstrate which of the following findings?

Question

A 40-year-old man comes to the physician because of a 2-year history of gradually worsening shortness of breath. He smoked half a pack of cigarettes daily for 10 years but stopped 8 years ago. His pulse is 72/min, blood pressure is 135/75 mm Hg, and respirations are 20/min. Examination shows an increased anteroposterior diameter of the chest. Diminished breath sounds are heard on auscultation of the chest. Spirometry shows an FEV1:FVC ratio of 63% and an FEV1 of 65% of predicted.   This patient's lower lung lobes are most likely to demonstrate which of the following findings?

Quizplus · Accepted Answer

Eductional Objective: Alpha-1 antitrypsin is the major serum inhibitor of neutrophil elastase.  Alpha-1 antitrypsin deficiency typically causes early-onset panacinar emphysema, predominantly affecting the lower lung lobes.

A 40-Year-Old Man Comes to the Physician Because of a 2-Year