A 65-year-old woman who experienced syncope after standing for a long time is currently being assessed. She used to work out at the neighborhood gym, but now she has trouble staying awake. The patient occasionally passes black stools. Due to "low appetite," she has lost 5 kg (11 lb) in the last few weeks. She doesn't smoke, drink, or use illegal substances. There is no family history of cancer. Orthostatic hypotension is modest, according to vital signs. Physical examination is uneventful, however occult blood in the stool is detectable. Two polyps are found during coloscopy. One polyp has advanced adenomatous alterations, and the other has adenocarcinoma, according to the pathology report. A mutation in which of the following genes is most likely responsible for the transformation from advanced adenoma to adenocarcinoma in this patient?

Question

Quizplus · Accepted Answer

Eductional Objective: The development of colon adenocarcinoma is caused by a sequence of gene changes known as the "adenoma to carcinoma sequence." The last phase in the process, TP53 tumor suppressor gene mutation, results in the malignant transformation of already large adenomatous polyps.

A 65-Year-Old Woman Who Experienced Syncope After Standing for a Long