A 22-Year-Old Woman Is Being Evaluated for Low Hemoglobin Level

A 22-year-old woman is being evaluated for low hemoglobin level. She has a history of heavy menstrual periods since menarche and also recalls frequent nosebleeds as a child. She has insignificant medical condition and she takes no medications. Laboratory studies show a hemoglobin level of 9.2 g/dL, a mean corpuscular volume of 72 fL, and decreased levels of ferritin. Which of the following is the most likely diagnosis?

A) Antiphospholipid syndrome
B) Factor VIII deficiency
C) Factor XIII deficiency
D) Immune thrombocytopenia
E) Protein C deficiency
F) von Willebrand factor deficiency