A 60-year-old man comes to the physician because of progressive pain in his right hip and lower back over the past 4 weeks. He describes the pain as dull and constant. It is worse with exertion and at night. Over the past 2 months, he has helped his son with renovating his home, which required heavy lifting and kneeling. His father died of prostate cancer. He drinks 2-3 beers daily. Vital signs are within normal limits. Examination shows localized tenderness over the right hip and groin area; range of motion is decreased. Hearing is mildly decreased on the right side. The remainder of the examination shows no abnormalities. Serum testing for which of the following would most likely help establish a diagnosis in this patient?

Question

Quizplus · Accepted Answer

Eductional Objective: Paget disease of bone is characterized by excessive and disordered bone formation.  It commonly affects the skull, long bones, and vertebral column.  The increased formation of new bone is associated with an elevated serum alkaline phosphatase level.  Radiographs shows lytic or mixed lytic-sclerotic lesions, thickening of cortical and trabecular bone, and bony deformities.

A 60-Year-Old Man Comes to the Physician Because of Progressive