A 65-year-old guy arrives at the clinic after experiencing 2 months of fatigue and a chronic, unproductive cough. He has a history of coronary artery disease and a heart attack. He underwent broad local excision of a melanoma on his posterior neck three years ago. The patient has a smoking history of 50 packs per year. The vital indicators are within normal ranges. A chest radiograph shows several lung abnormalities as well as hilar lymphadenopathy. After staining with hematoxylin and eosin, histopathology from one of the biopsied lung lesions is shown below. These histopathologic findings are most consistent with which of the following diagnoses?

Question

A 65-year-old guy arrives at the clinic after experiencing 2 months of fatigue and a chronic, unproductive cough. He has a history of coronary artery disease and a heart attack. He underwent broad local excision of a melanoma on his posterior neck three years ago. The patient has a smoking history of 50 packs per year. The vital indicators are within normal ranges. A chest radiograph shows several lung abnormalities as well as hilar lymphadenopathy. After staining with hematoxylin and eosin, histopathology from one of the biopsied lung lesions is shown below.  These histopathologic findings are most consistent with which of the following diagnoses?

Quizplus · Accepted Answer

Eductional Objective: Melanoma is a very aggressive cancer that frequently spreads early in the disease's progression. Patients may be asymptomatic for years until metastatic signs appear. A histopathologic sample is often used to make a diagnosis when it displays cellular atypia with cells carrying brown pigment (melanin granules); immunostaining for melanocytic markers (eg, S-100, HMB-45) is generally positive.

A 65-Year-Old Guy Arrives at the Clinic After Experiencing 2