A researcher is working to develop a new medication fot treatment fo patient with heart failure. if this treatment improve patient symptoms by increasing urine output and decreasing peripheral vascular resistance. The medication works by inhibiting a metalloprotease to prolong the action of endogenous polypeptides. These polypeptides are most likely secreted by which of the following cell types?

Question

A researcher is working to develop a new medication fot treatment fo patient with heart failure. if this treatment improve patient symptoms by increasing urine output and decreasing peripheral vascular resistance.  The medication works by inhibiting a metalloprotease to prolong the action of endogenous polypeptides.  These polypeptides are most likely secreted by which of the following cell types?

Quizplus · Accepted Answer

Eductional Objective: In heart failure patient with hypervolemia state, myocardial stretching stimulates secretion of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) from atrial and ventricular cardiomyocytes . This will cause a peripheral vasodilation and increased urinary excretion of sodium and water and inhibit the renin-angiotensin-aldosterone system.

A Researcher Is Working to Develop a New Medication Fot