A 50-year-old male comes to the office for routine follow up. He has a chronic kidney disease due to diabetic nephropathy. He has also hypertension and hyperlipidemia. Blood pressure is 140/85 mmHg and pulse is 85/min. weight is 82kg. Physical examinations are normal. Serum creatinine is 1.8 mg/dl and it has been increasing over the past 2 year. Serum calcium and phosphorus levels are in the normal range. Which of the following is most likely responsible for maintaining the serum phosphorus within normal range despite declining renal function?

Question

Quizplus · Accepted Answer

Eductional Objective: Fibroblast growth factor 23 is produced by osteocytes and increase production by hyperphosphatemia and 1,25-dihydroxyvitamin. In patient with chronic kidney disease may increase in serum phosphate level due to decrease in phosphate filtration. So increase FGF-23 leads to decrease intestinal phosphate absorption and renal reabsorption FGF23 levels are useful as an early marker of abnormal phosphate metabolism in patients with CKD.

A 50-Year-Old Male Comes to the Office for Routine Follow