As mean arterial blood pressure gradually rises, researchers are studying how coronary blood flow adapts (see graph below). 11ec160b 3c91 c4a0 9249 c159e35b6e4e MD0001 00 The slope's essentially horizontal section denotes a location where variations in blood pressure have little effect on coronary blood flow. The primary factor controlling coronary blood flow inside this zone of autoregulation is the myocardium's metabolic needs. Which of the following endogenous factors is most responsible for controlling coronary blood flow within this range?

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Eductional Objective: Over a wide range of perfusion pressures, coronary autoregulation enables myocardial oxygen demand to be the main driver of coronary blood flow (60-140 mm Hg). In reaction to myocardial hypoxia, adenosine and nitric oxide are released, altering vascular resistance primarily.

As Mean Arterial Blood Pressure Gradually Rises, Researchers Are Studying