A physiologist found during conducting a research experiment that glutamate depolarize and triggers cell death. he repeat this experiment by increasing magnesium concentration in the extracellular fluid and found that neuron depolarization and cell death due to glutamate are both decreased which of the following in ion electrolytes demonstrate decrease in cell death in response to magnesium?

Question

Quizplus · Accepted Answer

Eductional Objective: Excessive activation of the glutamate NMDA receptor causes excitotoxic neuronal death through uncontrolled calcium influx.  At the hyperpolarized resting membrane potential, the NMDA receptor is blocked by a magnesium plug, which is released by non-NMDA-mediated depolarization.

A Physiologist Found During Conducting a Research Experiment That Glutamate