A physiologist found during an experiment to study pancreatic enzymes that a mutation on the binding protein site on the trypsinogen molecule leads to inhibit the active trypsin moiety. This mutation prevents trypsin from being permanently inactivated by enzymatic cleavage. Patients with this mutation would most likely suffer from which of the following conditions?

Question

Quizplus · Accepted Answer

Eductional Objective: Multiple inhibitory mechanisms exist to prevent premature activation of trypsinogen before it reaches the duodenal lumen, including cleavage inactivation of trypsin by trypsin itself and production of trypsin inhibitors (eg, SPINK1).  Gene mutations that render trypsin insensitive to cleavage inactivation cause hereditary pancreatitis.

A Physiologist Found During an Experiment to Study Pancreatic Enzymes