An endocrainologist is trying to study the pathophysiology of insulin production. If he detects a mutation in the insulin gene. And this results in a single amino acid substitution in the proinsulin molecule. The endocrainologist concluds that the amino acid substitution affects a segment of proinsulin removed during post-translational processing of the protein. The polypeptide segment containing the mutation is most likely to undergo which of the following processes within pancreatic beta cells?

Question

An endocrainologist is trying to study the pathophysiology of insulin production. If he detects a mutation in the insulin gene. And this results in a single amino acid substitution in the proinsulin molecule. The endocrainologist concluds that the amino acid substitution affects a segment of proinsulin removed during post-translational processing of the protein.  The polypeptide segment containing the mutation is most likely to undergo which of the following processes within pancreatic beta cells?

Quizplus · Accepted Answer

Eductional Objective: Cleavage of proinsulin in pancreatic beta-cell secretory granules yields insulin and C-peptide, which are stored in the granules until they are secreted in equimolar amounts.

An Endocrainologist Is Trying to Study the Pathophysiology of Insulin