A 40-year-old man comes to hte office due to dizzy spills accompained by palpitations and sweating during exercise. He feels well if he drinks an orang juice or eat any sweat candy. The patient was diagnosed with type 2 diabetes 4months ago and advised to lose weight with dietary modification and exercise. Since then, he has been working out intensively and has lost 10 kg (22 lb). Which of the following mechanisms is responsible for this patient's symptoms when exercising?

Question

A 40-year-old man comes to hte office due to dizzy spills accompained by palpitations and sweating during exercise. He feels well if he drinks an orang juice or eat any sweat candy. The patient was diagnosed with type 2 diabetes 4months ago and advised to lose weight with dietary modification and exercise.  Since then, he has been working out intensively and has lost 10 kg (22 lb).  Which of the following mechanisms is responsible for this patient's symptoms when exercising?

Quizplus · Accepted Answer

Eductional Objective: Glucose uptake in skeletal muscle occurs primarily via glucose transporter (GLUT) 4.  Muscle contraction and insulin induce translocation of GLUT4 to the cell surface, increasing glucose uptake during exercise and the fed state, respectively.  Over time, regular exercise causes increased expression of GLUT4, leading to increased skeletal muscle glucose uptake at any given insulin level and therefore lower blood glucose levels.

A 40-Year-Old Man Comes to Hte Office Due to Dizzy