The Following Are True About Proton Sponge Effect EXCEPT

The following are true about proton sponge effect EXCEPT:

A) It describes the inflow of water and ions into endosomes and subsequent endosomal rupture and content release.
B) It is proportional to the number of ionizable amine groups in polymers.
C) It is more prominent in early endosomes than in late endosomes.
D) The more proton sponge effect,the higher intracellular bioavailability of DNA.
E) None of the above.