Endosomal Escape of DNA Complexes Can Be Enhanced By

Endosomal escape of DNA complexes can be enhanced by:

A) Enhanced proton sponge effect.
B) Stimuli-responsive lipids/polymers,such as pH-sensitive sulfhydryl reduction that results in membrane destabilization.
C) Endosomal enzymatic degradation that activate derivatives to fuse with the endosomal membrane and release DNA complexes.
D) Lysosomotrophic agents,such as chloroquine.
E) All of the above.