Which of the Following Statements About Using a Study Finding

Which of the following statements about using a study finding is the best guide?

A) A credible and clinically significant finding can with confidence be used as a basis for care.
B) A finding produced by a study done in a setting similar to the one in which the findings may be used can be used as a basis for care with confidence.
C) A study produced by a reputable organization can with confidence be used as a basis for care.
D) A credible and clinically significant finding of a study can be used as a basis for care after deliberation about its applicability.